Arsenic Trioxide

CAS Number: 1327-53-3

SERIOUS
health hazard

MODERATE
health hazard

FEW OR NO
health hazards

0 79
80 89
90 100
61

Sources of exposure:

Industrial uses
Medications

Prescription cancer treatments, glass manufacturing, metal processing, historical pesticide formulations, and arsenic-contaminated industrial sites

Description:

Arsenic trioxide is an inorganic arsenic compound used in certain industrial processes and as a prescription medication for specific forms of leukemia. It was also historically used in pesticides and other arsenic-containing preparations. Exposure may occur through medical administration, occupational handling, or contamination associated with historical industrial and agricultural activities.

Health concerns:

Cancer

Known or suspected to increase cancer risk in humans.

Genotoxicity

May cause mutations or damage DNA in cells.

Irritant

May cause skin, eye, or respiratory irritation.

Ecotoxicity

May be toxic to ecosystems and wildlife.

Banned/restricted lists:

  • EU REACH Annex XIV - Authorisation List - Subject to authorisation
  • EU REACH Candidate List (SVHC) - Candidate list
  • REACH Annex XVII - Restrictions - Restricted under specified conditions

References

  1. US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox).

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Hazard scores within 11 different health categories (carcinogens, endocrine disruptors, reproductive toxicants, developmental toxicants, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, skin/eye/respiratory irritants, and ecotoxicity).

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