Cyclotetrasiloxane (D4)

Synonyms: Octamethylcyclotetrasiloxane

CAS Number: 556-67-2

SERIOUS
health hazard

MODERATE
health hazard

FEW OR NO
health hazards

0 79

80 89

90 100

Sources of exposure:

Personal care

Food

Industrial use

Description:

Cyclotetrasiloxane is a cyclic silicone compound. It is used in personal care products as an emollient and hair-conditioning agent and as an intermediate in the production of silicone polymers. It is also used as an antifoaming agent in some food and beverage processing.

Health concerns:

Reproductive Toxicity

May alter hormone function and harm reproduction.

Ecotoxicity

May be toxic to ecosystems and wildlife.

Contaminants:

cyclic siloxanes

Banned/restricted lists:

European Commission Annex II prohibited substances.

References

US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox).

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We identified key chemicals based on a database compiling dozens of authoritative sources, screening tools, and QSAR models.

Hazard scores within 11 different health categories (carcinogens, endocrine disruptors, reproductive toxicants, developmental toxicants, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, skin/eye/respiratory irritants, and ecotoxicity).

They are weighted based on several factors, including strength of evidence for adverse impacts in humans, severity, and potential contamination.