GenX
Synonyms: Hexafluoropropylene Oxide (HFPO) Dimer Acid, HFPO Dimer Acid Ammonium Salt
CAS Number: 62037-80-3
Sources of exposure:
Contaminated soil and water; non-stick and heat resistant products such as cookware; electronics insulation
Description:
GenX chemicals are short-chain PFAS introduced as replacements for PFOA in the production of non-stick and chemically resistant materials. They may be released through industrial emissions, wastewater, and waste disposal and have been detected in air, rain, groundwater, and drinking water. GenX chemicals are highly mobile and extremely persistent in the environment. Because GenX chemicals are persistent, mobile, and associated with adverse health effects, this glossary applies a precautionary approach.
Health concerns:
Endocrine Disruption
May alter hormone function and contribute to chronic diseases and disorders.
Neurotoxicity
May impact brain function or development.
Organ System Toxicity
May cause organ damage and disease.
Immunotoxicity & Allergens
May impact immune system function or cause allergic reactions.
Irritant
May cause skin, eye, or respiratory irritation.
Ecotoxicity
May be toxic to ecosystems and wildlife.
Banned/restricted lists:
- REACH Substance of Very High Concern (SVHC)
- Minnesota Amara's Law
- California AB 1817-PFAS in textile articles
References
- US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox).
- US National Library of Medicine. PubChem database. US Environmental Protection Agency. 2021. Human Health Toxicity Values for Hexafluoropropylene Oxide (HFPO) Dimer Acid and Its Ammonium Salt (CASRN 13252-13-6 and CASRN (62037-80-3), Also Known as "GenX Chemicals". Substances of Very High Concern for REACH Annex XIV Authorisation (Article 59)