Propylene Oxide
CAS Number: 75-56-9
Sources of exposure:
Polyurethane foam manufacturing, chemical production, industrial sterilization, fumigation of certain food commodities, and occupational exposure
Description:
Propylene oxide is a volatile, reactive organic compound used primarily as a chemical intermediate in the production of polyether polyols and propylene glycol. It has also been used as a fumigant or sterilizing agent for certain food commodities and materials. Exposure may occur through industrial emissions, occupational handling, or residual amounts associated with treated products.
Health concerns:
Cancer
Known or suspected to increase cancer risk in humans.
Reproductive Toxicity
May alter hormone function and harm reproduction.
Genotoxicity
May cause mutations or damage DNA in cells.
Neurotoxicity
May impact brain function or development.
Organ System Toxicity
May cause organ damage and disease.
Immunotoxicity & Allergens
May impact immune system function or cause allergic reactions.
Respiratory Toxicity & Asthmagens
May damage the lungs or trigger asthma.
Irritant
May cause skin, eye, or respiratory irritation.
Banned/restricted lists:
- California Proposition 65 - OEHHA - cancer
- EU Cosmetics Regulation Annex II - Prohibited
- EU REACH Candidate List (SVHC) - Candidate list
- Health Canada Cosmetic Ingredient Hotlist - Prohibited
References
- US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox). California Department of Public Health. California Safe Cosmetics Reportable Ingredients List.