S,S,S-Tributyl phosphorotrithioate

Synonyms: DEF, Tribufos

CAS Number: 78-48-8

SERIOUS
health hazard

MODERATE
health hazard

FEW OR NO
health hazards

0 79

80 89

90 100

Sources of exposure:

Pesticides

Historical organophosphorus pesticide formulations, contaminated soil or water

Description:

S,S,S-Tributyl phosphorotrithioate, also known as DEF or tribufos, is an organophosphorus compound historically used as a cotton defoliant to promote leaf drop before harvesting. It has also been used in certain other agricultural applications. Exposure may occur during handling or application where permitted, or through residues associated with historical agricultural use.

Health concerns:

Cancer

Known or suspected to increase cancer risk in humans.

Neurotoxicity

May impact brain function or development.

Ecotoxicity

May be toxic to ecosystems and wildlife.

Banned/restricted lists:

California Proposition 65 - OEHHA - cancer

References

US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox).
California Department of Public Health. California Safe Cosmetics Reportable Ingredients List. US National Library of Medicine. PubChem database.

HOW MILLION MARKER SCORES CHEMICALS

Million Marker's Ingredient Hazard Scoring uses multiple chemical databases and a science-backed scoring system to compute hazard scores for thousands of chemicals found in consumer products and listed on ingredient labels.

We identified key chemicals based on a database compiling dozens of authoritative sources, screening tools, and QSAR models.

Hazard scores within 11 different health categories (carcinogens, endocrine disruptors, reproductive toxicants, developmental toxicants, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, skin/eye/respiratory irritants, and ecotoxicity).

They are weighted based on several factors, including strength of evidence for adverse impacts in humans, severity, and potential contamination.