Tetrahydrodiferuloylmethane

Synonyms: Tetrahydrocurcumin

CAS Number: 36062-04-1

SERIOUS
health hazard

MODERATE
health hazard

FEW OR NO
health hazards

0 79

80 89

90 100

Sources of exposure:

Personal care

Skincare serums, moisturizers, antioxidant cosmetic formulations

Description:

Tetrahydrodiferuloylmethane, also known as tetrahydrocurcumin, is a hydrogenated derivative of curcumin. It is used in personal care products as an antioxidant and skin-conditioning ingredient, including formulations intended to improve the appearance of skin tone.

Health concerns:

Genotoxicity

May cause mutations or damage DNA in cells.

References

US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox).

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We identified key chemicals based on a database compiling dozens of authoritative sources, screening tools, and QSAR models.

Hazard scores within 11 different health categories (carcinogens, endocrine disruptors, reproductive toxicants, developmental toxicants, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, skin/eye/respiratory irritants, and ecotoxicity).

They are weighted based on several factors, including strength of evidence for adverse impacts in humans, severity, and potential contamination.