Toluene Diisocyanate

Synonyms: TDI, Benzene, 1,3-diisocyanato-2-methyl-

CAS Number: 91-08-7

SERIOUS
health hazard

MODERATE
health hazard

FEW OR NO
health hazards

0 79

80 89

90 100

64

Sources of exposure:

Industrial use

Building materials, home goods, home maintenance products

Description:

Toluene diisocyanate is an aromatic diisocyanate primarily used to manufacture flexible polyurethane foams for furniture, mattresses, and automotive seating, as well as rigid foams used for insulation. It is also used in home maintenance products such as paints, sealants, and adhesives.

Health concerns:

Cancer

Known or suspected to increase cancer risk in humans.

Genotoxicity

May cause mutations or damage DNA in cells.

Immunotoxicity & Allergens

May impact immune system function or cause allergic reactions.

Respiratory Toxicity & Asthmagens

May damage the lungs or trigger asthma.

Irritant

May cause skin, eye, or respiratory irritation.

Ecotoxicity

May be toxic to ecosystems and wildlife.

Contaminants:

toluene diamine

Banned/restricted lists:

European Commission Annex II prohibited substances. Government of Canada. List of Ingredients that are Prohibited for Use in Cosmetic Products.

References

HOW MILLION MARKER SCORES CHEMICALS

Million Marker's Ingredient Hazard Scoring uses multiple chemical databases and a science-backed scoring system to compute hazard scores for thousands of chemicals found in consumer products and listed on ingredient labels.

We identified key chemicals based on a database compiling dozens of authoritative sources, screening tools, and QSAR models.

Hazard scores within 11 different health categories (carcinogens, endocrine disruptors, reproductive toxicants, developmental toxicants, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, skin/eye/respiratory irritants, and ecotoxicity).

They are weighted based on several factors, including strength of evidence for adverse impacts in humans, severity, and potential contamination.