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Trichloroethylene

Synonyms: TCE

CAS Number: 79-01-6

SERIOUS
health hazard

MODERATE
health hazard

FEW OR NO
health hazards

0 79
80 89
90 100
17

Sources of exposure:

Industrial use

Environmental pollution (soil, air, and water), occupational exposure

Description:

Trichloroethylene is a volatile organic compound (VOC) historically used as an industrial solvent and degreaser. It has largely been phased out of consumer products and dry cleaning due to toxicity and is high persistent in the environment. Trichloroethylene use is largely banned or restricted with ongoing cleanup of contaminated sites.

Health concerns:

Cancer

Known or suspected to increase cancer risk in humans.

Reproductive Toxicity

May alter hormone function and harm reproduction.

Developmental Toxicity

May impact fetal development and birth outcomes.

Genotoxicity

May cause mutations or damage DNA in cells.

Neurotoxicity

May impact brain function or development.

Organ System Toxicity

May cause organ damage and disease.

Immunotoxicity & Allergens

May impact immune system function or cause allergic reactions.

Respiratory Toxicity & Asthmagens

May damage the lungs or trigger asthma.

Irritant

May cause skin, eye, or respiratory irritation.

Ecotoxicity

May be toxic to ecosystems and wildlife.

Banned/restricted lists:

  • REACH Substance of Very High Concern (SVHC)

References

  1. US Environmental Protection Agency. Cheminformatics Modules, Computational Toxicology and Exposure Informatics (CompTox).
  2. California Department of Public Health. California Safe Cosmetics Reportable Ingredients List.
  3. US National Library of Medicine. PubChem database.

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We identified key chemicals based on a database compiling dozens of authoritative sources, screening tools, and QSAR models.

Hazard scores within 11 different health categories (carcinogens, endocrine disruptors, reproductive toxicants, developmental toxicants, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, skin/eye/respiratory irritants, and ecotoxicity).

They are weighted based on several factors, including strength of evidence for adverse impacts in humans, severity, and potential contamination.

For more information on our scoring methodology visit this page.